聯(lián)系我們時請說明是91化工儀器網(wǎng)上看到的信息,謝謝!
產(chǎn)品簡介 品牌 MedChemExpress (MCE) 貨號 HY-18629 規(guī)格 10 mM * 1 mL;5 mg;10 mg 供貨周期 現(xiàn)貨 應(yīng)用領(lǐng)域 生物產(chǎn)業(yè) SU9516 是一種有效的 CDK2 抑制劑,IC50 值為 22 nM,同時對 CDK1 和 CDK4 也有抑制作用,IC50 值分別為 40 和 200 nM。
詳細(xì)介紹 SU9516
產(chǎn)品活性:SU9516 是一種有效的 CDK2 抑制劑,IC50 值為 22 nM,同時對 CDK1 和 CDK4 也有抑制作用,IC50 值分別為 40 和 200 nM。
研究領(lǐng)域:Cell Cycle/DNA Damage | Autophagy
作用靶點:CDK | Autophagy
In Vitro: SU9516 shows slight activities against PKC, p38, PDGFr and EGFR, with IC50 of >10, >10, 18, and >100 μM. SU9516 (5 μM) decreases cdk2-specific Phosphorylation of pRB and inhibits cell cycle progression in RKO cells. SU9516 (5 μM) also induces apoptosis in RKO and SW480 Cells. SU9516 (5 μM) results in enhanced pRb/E2F complex formation in HT-29 cells. SU9516 enhances presence of E2F species in multiprotein complexes. SU9516 (5 μM) rapidly induces cytochrome crelease, Bax mitochondrial translocation, and apoptosis in association with pronounced down-regulation of the antiapoptotic protein Mcl-1. SU9516 causes down-regulation of Mcl-1 mRNA levels in human leukemia cells. Furthermore, SU9516 treatment results in a marked increase in reactive oxygen species production.
相關(guān)產(chǎn)品:Kinase Inhibitor Library | Anti-Cancer Compound Library | Cell Cycle/DNA Damage Compound Library | Bioactive Compound Library Plus | Autophagy Compound Library | Palbociclib | Abemaciclib methanesulfonate | Ribociclib | Dinaciclib | THZ531 | THZ1 | Seliciclib | NVP-2 | Ro-3306 | Flavopiridol | CYC065 | Atuveciclib Racemate | AZD4573 | GSK 3 Inhibitor IX | SNS-032 | SB1317 | Kenpaullone | CDK9-IN-2 | AZD-5438 | BS-181 | CT7001 hydrochloride | CCT-251921 | THZ2 | (+)-BAY-1251152 | AT7519
以上信息由企業(yè)自行提供,信息內(nèi)容的真實性、準(zhǔn)確性和合法性由相關(guān)企業(yè)負(fù)責(zé),91化工儀器網(wǎng)對此不承擔(dān)任何保證責(zé)任。溫馨提示:為規(guī)避購買風(fēng)險,建議您在購買產(chǎn)品前務(wù)必確認(rèn)供應(yīng)商資質(zhì)及產(chǎn)品質(zhì)量。 搜本商鋪 或 搜全站
MedChemExpress LLC - 主營產(chǎn)品: 西羅莫司 Rapamycin,瑞沙托維 TAK-242,奧拉帕尼 Olaparib
地址:上海市浦東新區(qū)張衡路1999弄3號樓 聯(lián)系電話:86-021-58955995 手機:18019480960 傳真:86-021-5370032591化工儀器網(wǎng) 設(shè)計制作,未經(jīng)允許翻錄必究 . Copyright(C) http://www.chem17.com, All rights reserved. 以上信息由企業(yè)自行提供,信息內(nèi)容的真實性、準(zhǔn)確性和合法性由相關(guān)企業(yè)負(fù)責(zé),91化工儀器網(wǎng)對此不承擔(dān)任何保證責(zé)任。
溫馨提示:為規(guī)避購買風(fēng)險,建議您在購買產(chǎn)品前務(wù)必確認(rèn)供應(yīng)商資質(zhì)及產(chǎn)品質(zhì)量。
會員登錄