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詳細(xì)介紹 JNJ-64619178
產(chǎn)品活性：JNJ-64619178 是一種偽不可逆的，選擇性 PRMT5 抑制劑，IC50 為 0.14 nM。
研究領(lǐng)域：Epigenetics
作用靶點(diǎn)：Histone Methyltransferase
In Vitro: JNJ-64619178 binds simultaneously to the S-adenosylmethionine (SAM)- and protein substrate- binding pockets of the PRMT5/MEP50 complex with a pseudo-irreversible mode-of-action. JNJ-64619178 shows potent and broad inhibition of cellular growth.
In Vivo: Oral administration of JNJ-64619178 results in efficient inhibition of dimethylation of SMD1/3 proteins, components of the splicing machinery and direct substrates of the methylosome, in several non-small cell lung cancer and small cell lung cancer cancer mouse xenograft models.
相關(guān)產(chǎn)品：Clinical Compound Library | Clinical Compound Library Plus | Anti-Cancer Compound Library | Epigenetics Compound Library | Bioactive Compound Library Plus | Histone Modification Research Compound Library | GSK126 | Tazemetostat | GSK343 | 3-Deazaneplanocin A hydrochloride | Pinometostat | UNC0642 | GSK3326595 | AZ505 ditrifluoroacetate | BIX-01294 | UNC1999 | EED226 | EPZ004777 | Chaetocin | SGC0946 | EPZ015666 | MS023 | EPZ031686 | MI-503 | EPZ015866 | LLY-507 | UNC0638 | A-366 | BCI-121 | CPI-1205 | UNC3866 | MI-463 | OICR-9429 | AMI-1 | GSK503 | UNC0321
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