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產(chǎn)品簡介 品牌 MedChemExpress (MCE) 貨號(hào) HY-12359 規(guī)格 10 mM * 1 mL；1 mg； 供貨周期 現(xiàn)貨 應(yīng)用領(lǐng)域 生物產(chǎn)業(yè)     TPPB是苯并內(nèi)酰胺衍生的可滲透細(xì)胞的蛋白激酶C （PKC） 活化物，Ki 值為11.9 nM。
詳細(xì)介紹 TPPB

產(chǎn)品活性：TPPB是苯并內(nèi)酰胺衍生的可滲透細(xì)胞的蛋白激酶C (PKC) 活化物，Ki 值為11.9 nM。

研究領(lǐng)域：Epigenetics | TGF-beta/Smad

作用靶點(diǎn)：PKC

In Vitro: By use of a cell line derived from an Alzheimer’s disease patient, significant enhancement of sAPPα secretion is achieved at 1 μM concentration for TPPB (Compound 5e). TPPB has a role against Aβ25-35-induced neurotoxicity in PC12 cells. TPPB at concentration of 1 μM could antagonize Aβ25-35 induced cell damage. TPPB could increase the phosphorylation of Akt, PKC, MARCKS and MAPK, which are inhibited by Aβ25-35 treatment. TPPB inhibits the activation of caspase-3 induced by Aβ25-35.

In Vivo: TPPB is evaluated for induction of hyperplasia after topical application to the shaved backs of outbred Sencar mice and shows a modest response at 300 μg.

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