奧地利BIOMEDICA 公司簡介
1978年Biomedica Gruppe公司成立主要業(yè)務(wù):銷售代理醫(yī)療器械及體外診斷產(chǎn)品,在歐洲和美國分設(shè)13個子公司。
公司總部位于奧地利首都維也納,全球員工人數(shù)250余人。1988年Biomedica Immunoassay公司成立主要從事研究、開發(fā)和生產(chǎn)基于ELISA方法學(xué)運用于臨床研究相關(guān)的檢測標(biāo)記物。
2009年Biomarker Design Forschungs GmbH(BDF)公司成立主要從事研究開發(fā)創(chuàng)新性的ELISA法生物標(biāo)記物。(例如:骨代謝或心血管疾病)
迄今Biomedica Immunoassay公司在心血管檢測及骨代謝檢測領(lǐng)域開發(fā)了一系列特色ELISA檢測試劑盒,并在世界各地設(shè)有代理商,銷售網(wǎng)絡(luò)遍布全球。BIOMEDICA ELISA檢測試劑盒 -----品質(zhì) 支持 靈活
通過ISO9001:2008認(rèn)證,獲得GMP/GLP認(rèn)證產(chǎn)品獲得CE認(rèn)證,用于臨床分析(*標(biāo)記只用于科研)分析標(biāo)本為人血清或血漿標(biāo)準(zhǔn)品和質(zhì)控品以人的血清或血漿為基質(zhì)提供細(xì)胞培養(yǎng)液分析的操作流程通用的96孔ELSIA板,可用于自動化分析可獨立使用一個96孔板或批量使用全球銷售
ELISA檢測生物標(biāo)記物-----用于臨床前和臨床研究
產(chǎn)品系列
中/英文名稱
應(yīng)用
骨代謝
硬骨素
Sclerostin(SOST)
骨代謝病檢測、骨質(zhì)疏松癥、shen病檢測、代謝病治療的療效檢測、風(fēng)濕性關(guān)節(jié)炎
Wnt通路抑制因子
Dickkopf-1*(DKK-1)
骨代謝疾病、Wnt信號通路
游離型可溶的RANKL
Free sRANKL
骨質(zhì)疏松癥、關(guān)節(jié)炎、癌癥研究
骨保護(hù)素
Osteoprotegerin(OPG)
骨質(zhì)疏松癥、關(guān)節(jié)炎、療效監(jiān)測、心血管疾病
組織蛋白酶K
Cathepsin K
骨質(zhì)疏松癥、炎癥反應(yīng)、骨吸收抑制藥監(jiān)測
骨轉(zhuǎn)換研究
心血管疾病
腦鈉肽前體
Nt-ProBNP
心衰、腎衰、糖尿病、高血壓
B型腦鈉肽
BNP
心衰、腎衰、糖尿病、高血壓
心鈉肽前體
proANP
心衰、心臟移植、心血管疾病
氨基酸末端C型利鈉肽前體
NT-proCNP
血管疾病、糖尿病、兒童骨骼發(fā)育、敗血癥
大內(nèi)皮素
Big Endothelin
心衰、急性心肌梗死、shen病、器官移植、動脈硬化、高血壓、硬皮癥
內(nèi)皮素
Endothelin
心衰、癌癥、內(nèi)皮功能紊亂、肝損傷、shen病、高血壓
內(nèi)皮抑制素
Endostatin
微血管損傷、慢性shen病、動脈硬化、貧血
氧化應(yīng)激
MDA氧化型低密度脂蛋白
MDA-oxLDL
動脈硬化、冠狀動脈疾病
過氧化物 Peroxides
冠心病、動脈硬化、敗血癥、炎癥反應(yīng)、癌癥
氧化低密度脂蛋白自身抗體
Autoantibodies against oxLDL(oLAB)
動脈硬化、心肌梗死、急性敗血癥、糖尿病
Sclerostin (SOST) ELISA Kit ( BI20492)
背景簡介:
在絕經(jīng)婦女、骨固定引起的骨質(zhì)流失患者、多重骨髓瘤患者Sclerostin水平顯著升高。經(jīng)甲狀旁腺素(PTH)和雌性激素持續(xù)治療后,血清Sclerostin水平降低。隨著Sclerostin和DKK-1中和抗體的開發(fā)研究,有望對于骨代謝疾病治療,獲得新進(jìn)展。
產(chǎn)品優(yōu)勢:
充分驗證可用于人血清、血漿樣本檢測。(尿標(biāo)本檢測參照對應(yīng)的protocol)樣本量小,只需20ul高靈敏度-正常值介于標(biāo)準(zhǔn)曲線,標(biāo)準(zhǔn)品2和標(biāo)準(zhǔn)品3值之間。6個校準(zhǔn)品+1個對照(標(biāo)準(zhǔn)品和對照均為人血清基質(zhì),檢測結(jié)果相關(guān)性更好)即用型檢測試劑盒試劑盒特點:
1)檢測方法:夾心ELISA,HRP/TMB顯色系統(tǒng)
2)樣本類型:血清、血漿(EDTA或肝素抗凝)、尿樣(參照對應(yīng)的protocol)
3)樣品量:20ul/test
4)標(biāo)準(zhǔn)品范圍:0-240 pmol/L
5)檢測靈敏度:2.6pmol/L
6)孵育條件:overnight/1h/30min(Room temperature)
7)單位轉(zhuǎn)換:1pg/ml=0.044pmol
參考文獻(xiàn):
1. Sclerostin: another bone-related protein related to all-cause mortality in haem dialysis? Viaene L et al., Nephrol Dial Transplant, 2013; 10.1093/ndt/gft039
2. The Relation between Renal Function and Serum Sclerostin in Adult Patients with CKD. Pelletier S et al., Clin J Am Soc Nephrol, 2013; 8: 819-823
3. Serum Sclerostin levels are associated with aortic valve calcification in prevalent ha-emodialysis patients. T rkvatan A et al., Nephrol Dial Transplant, 2013; 28: i19 i21
4. Circulating Sclerostin and Dickkopf-1 (DKK1) in predialysis chronic kidney disease (CKD): relationship with bone density and arterial stiffness. Thambiah S et al., Calcif Tissue Int, 2012; 90(6): 473-480
5. Circulating Sclerostin Levels and Bone Turnover in Type 1 and Type 2 Diabetes. Gennari L et al., J Clin Endo metab, 2012; 97: 1737-1744
6. Sclerostin and DKK-1 levels in pre-dialyisis CKD patients. Behets G et al., Nephrol Dial Transplant, 2012; 27: ii36-ii37
DKK-1 ELISA Kit (BI-20413)
背景簡介:
DKK-1和Sclerostins是wnt信號通路的有效的抑制劑,且在成骨細(xì)胞的分化過程中發(fā)揮重要作用。研究表明,骨形成減少、多發(fā)性骨髓瘤或由乳腺癌、前列腺癌、肺癌或關(guān)節(jié)炎引起的骨轉(zhuǎn)移,都可導(dǎo)致DKK-1水平升高。
產(chǎn)品優(yōu)勢:
當(dāng)日即可檢測直接測定,不許樣品稀釋。樣本需求量少,只需:20ul標(biāo)準(zhǔn)品范圍廣充分證實可用于人血清樣本檢測6個標(biāo)準(zhǔn)品+1個對照(均為血清基質(zhì))7)操作流程簡單
試劑盒特點:
1)檢測方法:夾心ELISA,HRP/TMB顯色系統(tǒng)
2)樣本類型:血清
3)樣品量:20ul/test
4)標(biāo)準(zhǔn)品范圍:0-160 pmol/L
5)檢測靈敏度:1.7pmol/L
6)孵育條件:2h/1h/30min
參考文獻(xiàn):
1. Elevated Serum Dickopff-1 Levels Increase Risk of Hip and Vertebral Fracture in Older Caucasian Women. Aarthi Arasu,et al. Endocr. Rev., Jun 2013; 34: SAT-224.
2. Genetic studies on components of the Wnt signalling pathway and the severity of joint destruction in rheumatoid arthritis. Diederik P C de Rooy,et al. Ann Rheum Dis, May 2013; 72: 769 - 775.
3. High dickkopf-1 levels in sera and leukocytes from children with 21-hydroxylase deficiency on chronic glucocorticoid treatment. Giacomina Brunetti,et al. Am J Physiol Endocrinol metab, Mar 2013; 304: E546 - E554.
4. The Effect of Zoledronic Acid on Serum Dickkopf-1, Osteoprotegerin, and RANKL
in Patients with Paget s Disease of Bone. S A Polyzos, et al. Horm metab Res, Aug 2009
5. Circulating Dickkopf-1 and Radiological Progression in Patients with Early Rheumatoid Arthritis Treated with Etanercept. Patrick Garnero,et al. J Rheumatol, Oct 2008
Endostain ELISA Kit (BI-20742 )
背景簡介:
Endostatin是一種內(nèi)源性的血管生成抑制劑。Endostatin在受傷腎組織的腎小管細(xì)胞纖維化進(jìn)程中高度表達(dá)。因此,Endostatin是慢性shen病檢測的潛在標(biāo)記物。對于微血管組織損傷病人包括:動脈硬化、腦缺血,Endostatin水平顯著升高。
產(chǎn)品優(yōu)勢:
檢測范圍寬6個即用型校準(zhǔn)品可當(dāng)日檢測,半小時內(nèi)出結(jié)果只需5ul樣本嚴(yán)格按照ICH要求,證實可用于人樣本檢測可靠、重復(fù)性好的實驗結(jié)果:批內(nèi)<6%,批間<5%試劑盒特點:
1)檢測方法:夾心ELISA,96孔,HRP/TMB顯色系統(tǒng)
2) 樣本類型:血清、血漿(檸檬酸鹽抗凝、EDTA抗凝、肝素抗凝)、尿(參照對應(yīng)的protocol)
3)樣品量:5ul
4)標(biāo)準(zhǔn)品范圍:0-80 nmol/L(0-1600ng/ml)
5)檢測靈敏度:0.02nmol/L(0+3SD)
6)孵育條件:2h/1h/30min,室溫
7)單位轉(zhuǎn)換:1 ng/ml = 0.05 nmol/l (MW = 20 kDa)
8)特異性:人樣本與其他種屬無交叉反應(yīng)
參考文獻(xiàn):
1. Elevated plasma levels of endostatin are associated with chronic kidney disease. J Chen, LL Hamm, et al.Am J Nephrol, Jan 2012; 35(4): 335-340
2. Early-onset coronary artery disease after pediatric kidney transplantation: implicatingthe angiogenesi inhibitor, endostatin. CW Iqbal,et al. Am Surg, Jun 2011; 77(6): 731-735
3. Immobilized kidney 28-kDa endostatin-related (KES28kDa) fragment promotes endothelial cell survival.MH Bellini, et al. Am J Nephrol, Jan 2010; 31(3): 255-261
4. Endostatin and angiostatin are increased in diabetic patients with coronary artery disease and associated with impaired coronary collateral formation. Neel R. Sodha, et al.Am J Physiol Heart Circ Physiol, Feb 2009; 296: H428-H434
NT-proBNP ELISA Kit (SK-1204)
背景簡介:
為什么要檢測NT-proBNP ?
NT-proBNP是 proBNP分解后的76氨基酸片段。proBNP是心臟為彌補(bǔ)收縮無力而增大時,心壁被拉伸時由心臟釋放到血液中的化學(xué)物質(zhì)。一旦從心臟釋放到血液中,proBNP就會分割為NT-proBNP和BNP。由于NT-proBNP的半衰期為120min,相比之下,BNP的半衰期僅20min。所以NT-proBNP可追蹤的時間可達(dá)24h而BNPzui多可監(jiān)測的時間為1h。因此,檢測血清/血漿中NT-proBNP穩(wěn)定性更好,檢測結(jié)果更可靠,是有效的心衰檢測工具。
產(chǎn)品優(yōu)勢:
性價比高可用于每個實驗室或開放實驗室CE 標(biāo)志-可用于臨床診斷簡單-傳統(tǒng)96孔板動態(tài)檢測范圍廣-可用于早期心衰檢測試劑盒特點:
檢測方法:夾心ELISA,HRP/TMB顯色
樣本類型:血清
樣品量:50ul/test
標(biāo)準(zhǔn)品范圍:0-640 pmol/L
檢測靈敏度:3pmol/L
孵育條件:3h/30min
單位換算:1pmol/L=8.475pg/ml
參考文獻(xiàn):
1. Infliximab Treatment Increases Left Ventricular Ejection Fraction in Patients with Rheumatoid Arthritis: Assessment of Heart Function by Echocardiography, Endothelin 1, Interleukin 6, and NT-pro Brain Natriuretic Peptide. PRZEMYSLAW J,et al. J Rheumatol, Apr 2012; 39: 701 - 706.
2. High-sensitivity troponin assay improves prediction of cardiovascular risk in patients with cerebral ischaemia. Raoul Stahrenberg,et al. J. Neurol. Neurosurg. Psychiatry, May 2013; 84: 479 - 487.
3. Diagnostic value of NT-proBNP in identifying aortic stenosis patients with heart failure. C Wu,et al. Zhonghua Xin Xue Guan Bing Za Zhi, Jul 2010; 38(7): 579-83.
BNP Fragment ELISA kit (BI-20852W)
背景簡介:
BNP是由心肌細(xì)胞合成的具有生物學(xué)活性的天然激素,主要在心室表達(dá),BNP是心臟衰竭重要的檢測指標(biāo),對于心臟衰竭具有重要的診斷價值。BNP與尿鈉排泄、多尿、血管舒張、腎素抑制、醛固酮分泌等生物功能密切相關(guān),在心血管功能穩(wěn)定中發(fā)揮重要的調(diào)節(jié)作用。
產(chǎn)品優(yōu)勢:
1)無需提取
2)直接檢測
3)樣品需求量少
4)可用于每個實驗室或開放實驗室
5)被測物穩(wěn)定
6)實驗結(jié)果重復(fù)性、可靠性高
試劑盒特點:
檢測方法:競爭ELISA,HRP/TMB顯色
樣本類型:血清、血漿
樣品量:30ul/test
標(biāo)準(zhǔn)品范圍:0-6400 pmol/L
檢測靈敏度:171pmol/L(=410pg/ml), at 95% B/B0
孵育條件:過夜/20min
參考文獻(xiàn):
Thirty years of the heart as an endocrine organ: physiological role and clinical utility of cardiac natriuretic hormones. Clerico A et al., Am J Physiol Heart Circ Physiol 2011; 301: H12-H20Comparison of Pleural Fluid N-Terminal Pro-Brain Natriuretic Peptide and Brain Natriuretic-32 Peptide Levels. Long AC et al., Chest 2010; 137: 1369-1374Natriuretic Peptides: New Players in Energy Homeostasis. Moro C and Smith RH, Diabetes 2009; 58: 27-26Natriuretic peptides: Markers or modulators of cardiac hypertrophy? Gardner DG, Trends Endocrinol metab 2003; 14: 411-416Processing of Pro B-Type Natriuretic Peptide: Furin and Corin as Candidate Convertases. Semenov AG et al., Clin Chem. 2010; 56:1166-1176Anti-c4d 抗體 (BI-RC4D-PE)
背景簡介:
C4d是抗體觸發(fā)補(bǔ)體通過經(jīng)典途徑活化后C4的裂解產(chǎn)物,能穩(wěn)定地結(jié)合在發(fā)生排斥的移植物內(nèi)皮的表面。檢測C4d作為機(jī)體針對同種異體移植物抗體檢測的一個間接信號,大量研究表明:C4d是腎移植免疫中的重要標(biāo)記物,同時也是心臟、肝及其他器官移植免疫檢測的重要標(biāo)記物。
產(chǎn)品優(yōu)勢:
用于檢測人C4d補(bǔ)體。該抗體可用于發(fā)光法或用One Lambda 公司的LABScreen Single Antigen beads流式檢測細(xì)胞內(nèi)或固相結(jié)合的C4或C4d片段。產(chǎn)品特點:
1) 檢測樣本:血清
2) 來源:兔多克隆抗體
3) 形式:50ul,PE 標(biāo)記純化的IgG片段。
4)應(yīng)用:Luminex -檢測、流式檢測石蠟及冰凍切片C4d補(bǔ)體。
參考文獻(xiàn):
1. C4d deposition is associated with inferior kidney allograft outcome independ.of cellular rejection. Regele H. et al., Nephrol Dial Transplant. 2001, 16(10): 2058-2066.
2. Capillary C4d deposition in kidney allografts: a specific marker of alloantibody-dependent graft injury. B hmig GA et al., J Am Soc Nephrol. 2002, 13(4): 1091-1099.
3. [C4d]FlowPRA screening a specific assay for selective detection of complement-activating anti-HLA alloantibodies. Wahrmann M et al., Hum Immunol, 2005, 66(5): 526-534
4. Pivotal role of complement-fixing HLA alloantibodies in presensitized kidney allograft recipients. Wahrmann M et al., Am J Transplant, 2006, 6: 1033-1041.
5. In vitro detection of C4d-fixing HLA alloantibodies: associations with capillary C4d deposition in kidney allografts. Bar G et al., Am J Transplant, 2008, 8(1): 41-49
6. Antibodies, isotypes and complement in allograft rejection. B hmig GA et al., Curr Opin Organ Transplant, 2008, 13(4): 411-418
7. Solid phase detection of C4d-fixing HLA antibodies to predict rejection in high immunological risk kidney transplant recipients. Bar G et al., Transpl Int. 2013; 26(2): 121-130.
產(chǎn)品目錄
類別
貨號
名稱
規(guī)格
骨代謝系列
BI-20492
Sclerostin (SOST) ELISA
1 Kit
BI-20413
DKK-1 ELISA
1 Kit
BI-20432
Cathepsin K ELISA Kit
1 Kit
BI-20403
OPG ELISA
1 Kit
BI-20452
sRANKL ELISA
1 Kit
心血管疾病
BI-20742
Endostatin ELISA
1 Kit
BI-20082H
Big Endothelin-1 ELISA
1 Kit
BI-20052
Endothelin ELISA
1 Kit
BI-20872
NT-proCNP ELISA
1 Kit
BI-20852W
BNP Fragment ELISA
1 Kit
SK-1204
NT-proBNP ELISA
1 Kit
BI-20892
proANP ELISA
1 Kit
動脈硬化
氧化應(yīng)激
BI-20032
Anti-Oxidized LDL (oLAB) ELISA
1 Kit
BI-5007
OxyStat Assay (Peroxides)ELISA
1 Kit
BI-20022
MDA-oxLDL ELISA
1 Kit
傳染病
BI-21032
Borrelia lgG ELISA
1 Kit
BI-21042
Borrelia lgM ELISA
1 Kit
BI-3501
Rheumatoid Factor Stripper
1 Kit
細(xì)胞增殖
BI-5000
EZ4U Cell Proliferation Assay
1 Kit
抗體
BI-RC4D
Polyclonal Anti-human C4d antibody
200ul
BI-RC4D-FITC
Polyclonal Anti-human C4d FITC Antibody
100 l
BI-RC4D-PE
Polyclonal Anti-human C4d PE Antibody
50 l
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