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詳細(xì)介紹 Acetylcysteine

產(chǎn)品活性：Acetylcysteine是一種粘液溶解劑，可以減少粘液的厚度。

研究領(lǐng)域：metabolic Enzyme/Protease

作用靶點(diǎn)：Endogenous metabolite

In Vitro: N-acetylcysteine prevents apoptotic DNA fragmentation and maintains long-term survival in the absence of other trophic support in serum-deprived PC12 cells. N-acetylcysteine also prevents death of PC12 cells and sympathetic neurons. N-acetylcysteine causes dose-dependent reductions in viability in rat and human aortic smooth muscle cells. N-acetylcysteine activates the Ras-extracellular signal-regulated kinase (ERK) pathway in PC12 cells. N-acetylcysteine protects neuronal cells from death evoked by withdrawal of trophic support. N-acetylcysteine increases nitric oxide (NO) release from protein-bound stores in vascular tissue. N-acetylcysteine pretreatment of PC12 cells interferes with NGF-dependent signaling and neurite outgrowth, and it is suggested that N-acetylcysteine interferes with redox-sensitive steps in the NGF mechanism.

In Vivo: N-acetylcysteine (150, 300 mg/kg) treatment significantly reduces liver transaminases in all groups of treatment, mostly in group N-acetylcysteine 300. Lung glutathione peroxidase is significantly increases in group N-acetylcysteine 300 (P=0.04), while the other oxidation biomarkers show no significant differences. N-acetylcysteine improves cognition of 12-month-old SAMP8 mice in both the T-maze footshock avoidance paradigm and the lever press appetitive task without inducing non-specific effects on motor activity, motivation to avoid shock, or body weight.

相關(guān)產(chǎn)品：Human Endogenous metabolite Compound Library | FDA-Approved Drug Library Mini | Peptidomimetic Library | Peptidomimetic Library | CNS-Penetrant Compound Library | Natural Product Library | FDA-Approved Drug Library | metabolism/Protease Compound Library | Bioactive Compound Library Plus | 3-Methyladenine | Hydrocortisone | Retinoic acid | Calcitriol | Estradiol | Melatonin | Prostaglandin E2 | ATP | Nicotinamide | Acetaminophen | Prostaglandin E1 | DHEA | Corticosterone | Docosahexaenoic Acid | Progesterone | Heparan Sulfate | NAD+ | Substance P | Protoporphyrin IX | L-Glutathione reduced | L-Epinephrine | β-Nicotinamide mononucleotide | L-DOPA | Adenosine | Dopamine hydrochloride | Hyaluronic acid | Theophylline | Eicosapentaenoic Acid | SDMA | Thymidine

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