羅斯河病毒（ rrv ）是傳送和蚊子是風(fēng)土在澳大利亞和巴布亞新幾內(nèi)亞。疾病所造成的rrv ，羅斯河熱（也稱為疫情多發(fā)性關(guān)節(jié)炎） ，是其中zui常見的法定傳染病在澳大利亞（約五〇 〇 〇案件每學(xué)年） （ 1 ） 。

RRV is transmitted via mosquitoesfound throughout Australia, particularly on the coast of QueenslandNew South Wales.  The virus may cause epidemic polyarthritis which can be extremely debilitating.  The average case of RRV infection lasts for 3 months, however joint painfatigue can persist for years.  Symptoms may varycan appear from 3 days to 3 weeks after being bitten by an infected mosquito (2). rrv是通過蚊子傳播的，發(fā)現(xiàn)在澳大利亞全國各地，特別是對海岸的昆士蘭和新南威爾士州。病毒可能會導(dǎo)致疫情多發(fā)性關(guān)節(jié)炎，可以非常衰弱。平均案件rrv感染歷時三個月，但關(guān)節(jié)疼痛和疲勞能堅(jiān)持了多年。癥狀可能會有所變動，并可以出現(xiàn)從3天到3周后，被咬傷感染的蚊子（ 2 ） 。
 

Immune response to RRV infection 免疫應(yīng)答rrv感染

Almost 100% of patients produce anti-RRV IgMIgG antibodies within two weeks of disease onset.  Anti-RRV IgG antibody persists for life, while IgM antibody is present for only 10-19 weeks after onset of symptoms in most patients.幾乎100 ％的病人產(chǎn)生反rrv IgM及IgG抗體的兩個星期內(nèi)發(fā)病。反rrv IgG抗體持續(xù)終身，而IgM抗體是目前只有10月19日周后，癥狀出現(xiàn)在大部分的病人。

 

Morphology 形態(tài) single strand, + sense RNA genome enclosed by capsid proteins單鏈， +義RNA基因組密封由衣殼蛋白 capsid surrounded by a host cell derived lipid envelope in which two glycoproteins (E1E2) are embedded as trimeric dimers衣殼包圍，由宿主細(xì)胞產(chǎn)生的脂質(zhì)信封，其中兩個糖蛋白（ E1和E2 ）的是嵌入式，作為trimeric二聚體 virions approximay 700 in diameter病毒粒子約700 ，直徑 an alphavirus, member of the family Togaviridae一甲，家庭成員togaviridae Symptoms 癥狀 Rash出疹的病征， Fever發(fā)燒 Headache頭痛 Aches in musclesjoints疼痛在肌肉和關(guān)節(jié) Diagnosis 診斷 isolation of virus from acute phase seronegative serum分離病毒從急性期血清血清 detection of anti-Ross River virus IgM antibody in a patient within 4 to 6 weeks of onset of polyarthritis檢測抗羅斯河病毒IgM抗體在病人4至6周發(fā)病的多發(fā)性關(guān)節(jié)炎 four-fold rise in anti-Ross River virus IgG or IgM antibody in paired sera collected 7 to 10 days aparttested in parallel 4倍上升，反羅斯河病毒IgG抗體或IgM抗體在配對血清中收集的7到10天，除了和測試在并行 Panbio RRV test kits panbio rrv測試工具

Panbio offers ELISA kits for the detection of anti-RRV IgG or IgM in human serum to assist in the diagnosis of Ross River fever.  Please click on the product of interest below to find out more. panbio提供ELISA檢測試劑盒檢測抗rrv IgG抗體或IgM抗體在人體血清，以協(xié)助診斷羅斯河熱。請點(diǎn)擊產(chǎn)品感興趣的下面了解更多信息。

Ross River IgG ELISA ＊ 羅斯河IgG抗體ELISA方法 ＊
Ross River IgM ELISA ＊ 羅斯河IgM酶聯(lián)免疫吸附 ＊

Prevention 預(yù)防 mosquito avoidance the virus can only spread by mosquito bite蚊子避稅-病毒只能傳播蚊蟲叮咬 screen houses屏幕房子 cover up when likely to be exposed to mosquitoes掩蓋時，可能會接觸到的蚊子 eliminate mosquito breeding sites in or near residential areas清除蚊子滋生地點(diǎn)或附近的住宅區(qū) vaccine is under development, but not yet available for human use疫苗是根據(jù)發(fā)展，但尚未備妥，供人類使用 Current situation 現(xiàn)狀

The number of Ross River virus (RRV) notifications in Australia has been on the rise since 2002.  Most cases are reported in Queensland, however considerable RRV activity has been observed in Western Australia recently.人數(shù)羅斯河病毒（ rrv ）的通知，在澳大利亞一直在增加，自2002年以來，大多數(shù)情況下，據(jù)報(bào)道，在昆士蘭州，但相當(dāng)rrv活動已觀察到在西澳大利亞州zui近。