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產(chǎn)品簡(jiǎn)介 品牌 MedChemExpress (MCE) 貨號(hào) HY-15405 規(guī)格 10 mM * 1 mL；10 mg；50 mg 供貨周期 現(xiàn)貨 應(yīng)用領(lǐng)域 生物產(chǎn)業(yè)     Teriflunomide是來(lái)氟米特的活性代謝產(chǎn)物，是用于治療類風(fēng)濕性關(guān)節(jié)炎的藥物。 它抑制嘧啶合成，因此有效降低T細(xì)胞和B細(xì)胞增殖。
詳細(xì)介紹 Teriflunomide

產(chǎn)品活性：Teriflunomide是來(lái)氟米特的活性代謝產(chǎn)物，是用于治療類風(fēng)濕性關(guān)節(jié)炎的藥物。 它抑制嘧啶合成，因此有效降低T細(xì)胞和B細(xì)胞增殖。

研究領(lǐng)域：Others

作用靶點(diǎn)：Others

In Vitro: Teriflunomide primarily acts as an inhibitor of dihydroorotate dehydrogenase (DHODH), a key mitochondrial enzyme involved in the de novo synthesis of pyrimidines in rapidly proliferating cells. By reducing the activity of high-avidity proliferating T lymphocytes and B lymphocytes, teriflunomide likely attenuates the inflammatory response to autoantigens in MS. Thus, teriflunomide can be considered a cytostatic rather than a cytotoxic drug to leukocytes.

In Vivo: Teriflunomide has demonstrated beneficial effects in two independent animal models of demyelinating disease. In the dark agouti rat model of experimental autoimmune encephalitis (EAE), teriflunomide administration results in clinical, histopathological, and electrophysiological evidence of efficacy both as a prophylactic and therapeutic agent. Similarly, in the female Lewis rat model of EAE, teriflunomide administration results in beneficial prophylactic and therapeutic clinical effects, with a delay in disease onset and symptom severity.

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