聯(lián)系我們時(shí)請(qǐng)說明是91化工儀器網(wǎng)上看到的信息，謝謝!

產(chǎn)品簡介 品牌 MedChemExpress (MCE) 貨號(hào) HY-17427 規(guī)格 10 mM * 1 mL；50 mg；100 mg 供貨周期 現(xiàn)貨 應(yīng)用領(lǐng)域 生物產(chǎn)業(yè)     Emtricitabine is a nucleoside reverse transcriptase inhibitor （NRTI） with an EC50 of 0.01 #181;M in PBMC cell. It is an antiviral drug for the treatment of HIV infection.
詳細(xì)介紹 Emtricitabine

產(chǎn)品活性：Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) with an EC50 of 0.01 M in PBMC cell. It is an antiviral drug for the treatment of HIV infection.

研究領(lǐng)域：Anti-infection

作用靶點(diǎn)：HIV | Reverse Transcriptase

In Vitro: Emtricitabine has in vitro activity against both laboratory strains of HIV-1 and HIV-2 and clinical isolates of HIV-1. The 50% effective concentration (EC50) ranges from 0.002 to 1.5 mol/L, depending on the viral isolate and cell line used. Emtricitabine demonstrates in vitro synergy with zidovudine and stavudine and additive in vitro activity when combines with zalcitabine or didanosine.

In Vivo: Reproductive and developmental toxicology studies are conducted with emtricitabine. Oral doses up to 1000 mg/kg/day provided daily area under the curve (AUC0 24) exposure to pregnant animals approximately 60- (mice) to 120-fold (rabbits) higher than that in humans at the recommended dose of 200 mg given once per day. In a mouse fertility study, emtricitabine had no effect on fertility, sperm count, or early embryonic development. There is no increased incidence of malformations in mouse and rabbit embryofetal toxicology studies. The development and fertility of F1 progeny are unaffected by emtricitabine in a mouse pre- and post-natal study. These data demonstrate a favorable pre-clinical reproductive safety profile for emtricitabine.

相關(guān)產(chǎn)品：FDA-Approved Drug Library Plus | Drug Repurposing Compound Library | Anti-Infection Compound Library | FDA-Approved Drug Library Mini | Anti-Virus Compound Library | CNS-Penetrant Compound Library | FDA-Approved Drug Library | Drug Repurposing Compound Library Plus | Bioactive Compound Library Plus | Dolutegravir | Maraviroc | Cenicriviroc | Ritonavir | Ebselen | Bictegravir | Tenofovir Disoproxil Fumarate | Lamivudine | Efavirenz | Atazanavir sulfate | Raltegravir potassium salt | Tipranavir | Triciribine | Mavorixafor trihydrochloride | Elvitegravir | Saquinavir | Betulinic acid | Zidovudine | Delavirdine mesylate | Miltefosine | Nelfinavir Mesylate | TAK-779 | Lopinavir | Abacavir | Cabotegravir | Etravirine | Nevirapine | Stavudine

以上信息由企業(yè)自行提供，信息內(nèi)容的真實(shí)性、準(zhǔn)確性和合法性由相關(guān)企業(yè)負(fù)責(zé)，91化工儀器網(wǎng)對(duì)此不承擔(dān)任何保證責(zé)任。
溫馨提示：為規(guī)避購買風(fēng)險(xiǎn)，建議您在購買產(chǎn)品前務(wù)必確認(rèn)供應(yīng)商資質(zhì)及產(chǎn)品質(zhì)量。 搜本商鋪 或 搜全站

MedChemExpress LLC - 主營產(chǎn)品： 西羅莫司 Rapamycin,瑞沙托維 TAK-242,奧拉帕尼 Olaparib

地址：上海市浦東新區(qū)張衡路1999弄3號(hào)樓      聯(lián)系電話：86-021-58955995      手機(jī)：18019480960     傳真：86-021-53700325
91化工儀器網(wǎng) 設(shè)計(jì)制作，未經(jīng)允許翻錄必究 .      Copyright(C) http://www.chem17.com,      All rights reserved. 以上信息由企業(yè)自行提供，信息內(nèi)容的真實(shí)性、準(zhǔn)確性和合法性由相關(guān)企業(yè)負(fù)責(zé)，91化工儀器網(wǎng)對(duì)此不承擔(dān)任何保證責(zé)任。
溫馨提示：為規(guī)避購買風(fēng)險(xiǎn)，建議您在購買產(chǎn)品前務(wù)必確認(rèn)供應(yīng)商資質(zhì)及產(chǎn)品質(zhì)量。
會(huì)員登錄